Blar i forfatter "Fellner, Matthias"

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    • Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response 

      Fellner, Matthias; Walsh, Annabel; Ahator, Stephen Dela; Aftab, Nadia; Sutherland, Ben; Tan, Eng W; Bakker, Alexander T; Martin, Nathaniel I; van der Stelt, Mario; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful tools for profiling and identifying novel druggable target candidates, but their functions often remain uncharacterized. Previously, we used activity-based protein profiling in the opportunistic pathogen Staphylococcus ...

    • Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus 

      Fellner, Matthias; Lentz, Christian; Jamieson, Sam A; Brewster, Jodi L; Chen, Linhai; Bogyo, Matthew; Mace, Peter D (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-31)
      Staphylococcus aureus is a prevalent bacterial pathogen in both community and hospital settings, and its treatment is made particularly difficult by resilience within biofilms. Within this niche, serine hydrolase enzymes play a key role in generating and maintaining the biofilm matrix. Activity-based profiling has previously identified a family of serine hydrolases, designated fluorophosphonate-binding ...